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Rapid weight reductioncommon in the first months of treatment with these medicationsmay not allow sufficient time for physiological adaptation

However, the precautions remain the same

Always confirm with your plan administrator before starting any treatment

Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023

Both semaglutide and tirzepatide belong to this class of medications, but they work in slightly different ways